Inhaled ipratropium [i-pra-TROE-pee-um], a quaternary derivative of atropine, is useful in treating asthma in patients who are unable to take adrenergic agonists. Ipratropium is also beneficial in the management of chronic obstructive pulmonary disease. It is inhaled for these conditions. Because of its positive charge, it does not enter the systemic circulation or the CNS, isolating its effects to the pulmonary system. Important characteristics of the muscarinic antagonists are summarized in Figures 5.6 and 5.7
Figure : Adverse effects commonly observed with cholinergic antagonists.
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