Demecarium [dem-e-KARE-ee-um] is another cholinesterase inhibitor used to treat chronic open-angle glaucoma (primarily in patients refractory to other agents) closed-angle glaucoma after irredectomy. It is also used for the diagnosis and treatment of accommodative esotropia. Demecarium is a quaternary amine that is structurally related to neostigmine. Mechanisms of actions and side effects are similar to those of neostigmine.

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